Leading scholar Louis Feldman stated that the discovery of Pines "created a considerable stir" in the academic community by drawing attention to two important historical works which had been almost completely neglected before then. Pines also discovered a 12th-century Syriac version of Josephus by Michael the Syrian. In 1971 Pines discovered a 10th-century Arabic version of the Testimonium Flavianum by Josephus due to Agapius of Hierapolis. In the young State of Israel, Pines was a professor in the Department of Jewish Thought and the Department of Philosophy at the Hebrew University of Jerusalem from 1952 until his death in 1990. In 1940, he and his family departed for Palestine on the last boat leaving Marseilles before the Nazi occupation of France (during which time 25% of French Jews were deported and murdered).
From 1937 to 1939 he taught the history of science in Islamic countries at the Institute of the History of Science in Paris. Among his friends at Berlin were Paul Kraus and Leo Strauss, the latter of whom would contribute the lengthy introductory essay to Pines' classic translation of The Guide.
His father, Meir Pines, was a scholar and businessman whose Sorbonne dissertation comprised the first attempt at a history of Yiddish literature.Ä«etween 19 Shlomo Pines studied philosophy, Semitic languages, and linguistics at the universities of Heidelberg, Geneva and Berlin. Pines was born in Charenton-le-Pont near Paris, and grew up in Paris, Riga, Archangelsk, London and Berlin.